<?xml version="1.0" encoding="ISO-8859-1" standalone="yes"?>
<CourseDefinition>
  <Schema>
    <Version>3.0</Version>
    <Date>20120717</Date>
  </Schema>
  <Details>
    <RegimId>NRB-13601</RegimId>
    <Name>HAM &gt; 1 år eller &gt; 10 kg</Name>
    <ShortName/>
    <MajorVersion>1</MajorVersion>
    <MinorVersion>3</MinorVersion>
    <DefinitionStatus>COMPLETED</DefinitionStatus>
    <PatientMaxSurface/>
    <CourseICDZCode>NONE</CourseICDZCode>
    <CourseAUC>0.00</CourseAUC>
    <MaxAge/>
    <CycleLength/>
    <ValidForAllDiagnoses/>
    <IsStudyDefinition>NO</IsStudyDefinition>
    <PhysicianComment>Emetogenicitet:Hög.\n\nDiagnoskod: C 92.\n\n</PhysicianComment>
    <NurseComment/>
    <PharmacistComment/>
    <PatientComment/>
    <ExternalDocumentation/>
    <ExternalPhysicianDoc>https://kunskapsbanken.cancercentrum.se/redirect/regim/13601</ExternalPhysicianDoc>
    <ExternalNurseDoc>https://kunskapsbanken.cancercentrum.se/redirect/regim/13601</ExternalNurseDoc>
    <ExternalPharmacistDoc/>
    <ExternalPatientDoc/>
    <Rounding/>
    <HasSteps/>
  </Details>
  <Miscellaneous>
    <OriginOfExport>Regimbiblioteket</OriginOfExport>
    <IsAuthorized/>
    <CommittedBy/>
    <CreatedBy/>
    <CreatedDate>20260408</CreatedDate>
  </Miscellaneous>
  <Diagnoses>
    <Diagnose Text="Akut myeloisk leukemi (AML)"/>
  </Diagnoses>
  <Protocols/>
  <AdditionalInformation/>
  <DoseSteps>
    <Steps Id="272">
      <Name>Metotrexat it</Name>
      <Qualifier>AGEYEARS</Qualifier>
      <FluidSteps>NO</FluidSteps>
      <Contents>
        <Step>
          <StepFrom>0.00</StepFrom>
          <StepTo>1.00</StepTo>
          <StepValue>6</StepValue>
          <StepCalculation>NONE</StepCalculation>
          <InfusionTime>-1</InfusionTime>
        </Step>
        <Step>
          <StepFrom>1.00</StepFrom>
          <StepTo>2.00</StepTo>
          <StepValue>8</StepValue>
          <StepCalculation>NONE</StepCalculation>
          <InfusionTime>-1</InfusionTime>
        </Step>
        <Step>
          <StepFrom>2.00</StepFrom>
          <StepTo>3.00</StepTo>
          <StepValue>10</StepValue>
          <StepCalculation>NONE</StepCalculation>
          <InfusionTime>-1</InfusionTime>
        </Step>
        <Step>
          <StepFrom>3.00</StepFrom>
          <StepTo> 999999.99</StepTo>
          <StepValue>12</StepValue>
          <StepCalculation>NONE</StepCalculation>
          <InfusionTime>-1</InfusionTime>
        </Step>
      </Contents>
    </Steps>
  </DoseSteps>
  <Days>
    <Day Number="1">
      <Details>
        <Name/>
        <ConfirmationMandatory>NO</ConfirmationMandatory>
        <Comment/>
      </Details>
      <CriticalParameters/>
      <Lines>
        <Line Number="1">
          <Details>
            <Type>SUBSTANCE</Type>
            <Route>IT</Route>
            <InfusionHours>0</InfusionHours>
            <InfusionMinutes>0</InfusionMinutes>
            <ProductionBy>PHARMACY</ProductionBy>
            <RelationType>NONE</RelationType>
          </Details>
          <Substance Name="metotrexat">
            <Dose Max="">0</Dose>
            <Steps>272</Steps>
            <Unit>MG</Unit>
            <Calculation>STANDARD</Calculation>
          </Substance>
          <Fluid Name="Ingen spädning">
            <Volume/>
            <Unit/>
            <Calculation/>
          </Fluid>
          <Comments>
            <Comment Text="Trombocyter ska vara &gt;50, annars ges trombocyt inf direkt före LP\nVid CNS engagemang ges intratekal trippel istället"/>
          </Comments>
        </Line>
        <Line Number="2">
          <Details>
            <Type>FLUID</Type>
            <Route>IVINF</Route>
            <InfusionHours>24</InfusionHours>
            <InfusionMinutes>0</InfusionMinutes>
            <ProductionBy>WARD</ProductionBy>
            <RelationType>DAY</RelationType>
            <RelatedToDayNumber>0</RelatedToDayNumber>
            <RelatedToLineNumber>0</RelatedToLineNumber>
            <RelationOffset>0</RelationOffset>
          </Details>
          <Fluid Name="Plasmalyte">
            <Volume>2000</Volume>
            <Steps>0</Steps>
            <Unit>ML</Unit>
            <Calculation>SURFACE</Calculation>
          </Fluid>
          <Comments>
            <Comment Text="Intravenös infusion - hydrering"/>
            <Comment Text="= totalvätska, man kan räkna av intag som tas per oralt. Vätska ges i samband med kemoterapi och ett par timmar efter Cytarabin."/>
          </Comments>
        </Line>
        <Line Number="3">
          <Details>
            <Type>SUBSTANCE</Type>
            <Route>IVINF</Route>
            <InfusionHours>2</InfusionHours>
            <InfusionMinutes>0</InfusionMinutes>
            <ProductionBy>PHARMACY</ProductionBy>
            <RelationType>DAY</RelationType>
            <RelatedToDayNumber>0</RelatedToDayNumber>
            <RelatedToLineNumber>0</RelatedToLineNumber>
            <RelationOffset>0</RelationOffset>
          </Details>
          <Substance Name="cytarabin">
            <Dose Max="">1000</Dose>
            <Steps>0</Steps>
            <Unit>MG</Unit>
            <Calculation>SURFACE</Calculation>
          </Substance>
          <Fluid Name="Natriumklorid 9 mg/ml">
            <Volume>100</Volume>
            <Steps>0</Steps>
            <Unit>ML</Unit>
            <Calculation/>
          </Fluid>
          <Comments>
            <Comment Text="Kortison ögondroppar, 1 dr i vardera öga 3-4 ggr/dygn, förbygger cytarabin inducerad konjunktivit"/>
          </Comments>
        </Line>
        <Line Number="4">
          <Details>
            <Type>SUBSTANCE</Type>
            <Route>IVINF</Route>
            <InfusionHours>2</InfusionHours>
            <InfusionMinutes>0</InfusionMinutes>
            <ProductionBy>PHARMACY</ProductionBy>
            <RelationType>START</RelationType>
            <RelatedToDayNumber>1</RelatedToDayNumber>
            <RelatedToLineNumber>3</RelatedToLineNumber>
            <RelationOffset>720</RelationOffset>
          </Details>
          <Substance Name="cytarabin">
            <Dose Max="">1000</Dose>
            <Steps>0</Steps>
            <Unit>MG</Unit>
            <Calculation>SURFACE</Calculation>
          </Substance>
          <Fluid Name="Natriumklorid 9 mg/ml">
            <Volume>100</Volume>
            <Steps>0</Steps>
            <Unit>ML</Unit>
            <Calculation/>
          </Fluid>
          <Comments/>
        </Line>
      </Lines>
    </Day>
    <Day Number="2">
      <Details>
        <Name/>
        <ConfirmationMandatory>NO</ConfirmationMandatory>
        <Comment/>
      </Details>
      <CriticalParameters/>
      <Lines>
        <Line Number="1">
          <Details>
            <Type>FLUID</Type>
            <Route>IVINF</Route>
            <InfusionHours>24</InfusionHours>
            <InfusionMinutes>0</InfusionMinutes>
            <ProductionBy>WARD</ProductionBy>
            <RelationType>START</RelationType>
            <RelatedToDayNumber>1</RelatedToDayNumber>
            <RelatedToLineNumber>2</RelatedToLineNumber>
            <RelationOffset>1440</RelationOffset>
          </Details>
          <Fluid Name="Plasmalyte">
            <Volume>2000</Volume>
            <Steps>0</Steps>
            <Unit>ML</Unit>
            <Calculation>SURFACE</Calculation>
          </Fluid>
          <Comments>
            <Comment Text="Intravenös infusion - hydrering"/>
            <Comment Text="= totalvätska, man kan räkna av intag som tas per oralt. Vätska ges i samband med kemoterapi och ett par timmar efter Cytarabin."/>
          </Comments>
        </Line>
        <Line Number="2">
          <Details>
            <Type>SUBSTANCE</Type>
            <Route>IVINF</Route>
            <InfusionHours>2</InfusionHours>
            <InfusionMinutes>0</InfusionMinutes>
            <ProductionBy>PHARMACY</ProductionBy>
            <RelationType>START</RelationType>
            <RelatedToDayNumber>1</RelatedToDayNumber>
            <RelatedToLineNumber>4</RelatedToLineNumber>
            <RelationOffset>720</RelationOffset>
          </Details>
          <Substance Name="cytarabin">
            <Dose Max="">1000</Dose>
            <Steps>0</Steps>
            <Unit>MG</Unit>
            <Calculation>SURFACE</Calculation>
          </Substance>
          <Fluid Name="Natriumklorid 9 mg/ml">
            <Volume>100</Volume>
            <Steps>0</Steps>
            <Unit>ML</Unit>
            <Calculation/>
          </Fluid>
          <Comments>
            <Comment Text="Kortison ögondroppar, 1 dr i vardera öga 3-4 ggr/dygn, förbygger cytarabin inducerad konjunktivit"/>
          </Comments>
        </Line>
        <Line Number="3">
          <Details>
            <Type>SUBSTANCE</Type>
            <Route>IVINF</Route>
            <InfusionHours>2</InfusionHours>
            <InfusionMinutes>0</InfusionMinutes>
            <ProductionBy>PHARMACY</ProductionBy>
            <RelationType>START</RelationType>
            <RelatedToDayNumber>2</RelatedToDayNumber>
            <RelatedToLineNumber>2</RelatedToLineNumber>
            <RelationOffset>720</RelationOffset>
          </Details>
          <Substance Name="cytarabin">
            <Dose Max="">1000</Dose>
            <Steps>0</Steps>
            <Unit>MG</Unit>
            <Calculation>SURFACE</Calculation>
          </Substance>
          <Fluid Name="Natriumklorid 9 mg/ml">
            <Volume>100</Volume>
            <Steps>0</Steps>
            <Unit>ML</Unit>
            <Calculation/>
          </Fluid>
          <Comments/>
        </Line>
      </Lines>
    </Day>
    <Day Number="3">
      <Details>
        <Name/>
        <ConfirmationMandatory>NO</ConfirmationMandatory>
        <Comment/>
      </Details>
      <CriticalParameters/>
      <Lines>
        <Line Number="1">
          <Details>
            <Type>FLUID</Type>
            <Route>IVINF</Route>
            <InfusionHours>24</InfusionHours>
            <InfusionMinutes>0</InfusionMinutes>
            <ProductionBy>WARD</ProductionBy>
            <RelationType>START</RelationType>
            <RelatedToDayNumber>2</RelatedToDayNumber>
            <RelatedToLineNumber>1</RelatedToLineNumber>
            <RelationOffset>1440</RelationOffset>
          </Details>
          <Fluid Name="Plasmalyte">
            <Volume>2000</Volume>
            <Steps>0</Steps>
            <Unit>ML</Unit>
            <Calculation>SURFACE</Calculation>
          </Fluid>
          <Comments>
            <Comment Text="Intravenös infusion - hydrering"/>
            <Comment Text="= totalvätska, man kan räkna av intag som tas per oralt. Vätska ges i samband med kemoterapi och ett par timmar efter Cytarabin."/>
          </Comments>
        </Line>
        <Line Number="2">
          <Details>
            <Type>SUBSTANCE</Type>
            <Route>IVINF</Route>
            <InfusionHours>2</InfusionHours>
            <InfusionMinutes>0</InfusionMinutes>
            <ProductionBy>PHARMACY</ProductionBy>
            <RelationType>START</RelationType>
            <RelatedToDayNumber>2</RelatedToDayNumber>
            <RelatedToLineNumber>3</RelatedToLineNumber>
            <RelationOffset>720</RelationOffset>
          </Details>
          <Substance Name="cytarabin">
            <Dose Max="">1000</Dose>
            <Steps>0</Steps>
            <Unit>MG</Unit>
            <Calculation>SURFACE</Calculation>
          </Substance>
          <Fluid Name="Natriumklorid 9 mg/ml">
            <Volume>100</Volume>
            <Steps>0</Steps>
            <Unit>ML</Unit>
            <Calculation/>
          </Fluid>
          <Comments>
            <Comment Text="Kortison ögondroppar, 1 dr i vardera öga 3-4 ggr/dygn, förbygger cytarabin inducerad konjunktivit"/>
          </Comments>
        </Line>
        <Line Number="3">
          <Details>
            <Type>ANTIDOTE</Type>
            <Route>IVINF</Route>
            <InfusionHours>0</InfusionHours>
            <InfusionMinutes>15</InfusionMinutes>
            <ProductionBy>WARD</ProductionBy>
            <RelationType>END</RelationType>
            <RelatedToDayNumber>3</RelatedToDayNumber>
            <RelatedToLineNumber>2</RelatedToLineNumber>
            <RelationOffset>0</RelationOffset>
          </Details>
          <Substance Name="dexrazoxan">
            <Dose Max="">500</Dose>
            <Steps>0</Steps>
            <Unit>MG</Unit>
            <Calculation>SURFACE</Calculation>
          </Substance>
          <Fluid Name="Specialspädning">
            <Volume/>
            <Unit/>
            <Calculation/>
          </Fluid>
          <Comments>
            <Comment Text="VIKTIGT att Mitoxantron startas direkt efter avslutad Dexrazoxan"/>
          </Comments>
        </Line>
        <Line Number="4">
          <Details>
            <Type>SUBSTANCE</Type>
            <Route>IVINF</Route>
            <InfusionHours>1</InfusionHours>
            <InfusionMinutes>0</InfusionMinutes>
            <ProductionBy>PHARMACY</ProductionBy>
            <RelationType>END</RelationType>
            <RelatedToDayNumber>3</RelatedToDayNumber>
            <RelatedToLineNumber>3</RelatedToLineNumber>
            <RelationOffset>0</RelationOffset>
          </Details>
          <Substance Name="mitoxantron">
            <Dose Max="">10</Dose>
            <Steps>0</Steps>
            <Unit>MG</Unit>
            <Calculation>SURFACE</Calculation>
          </Substance>
          <Fluid Name="Natriumklorid 9 mg/ml">
            <Volume>100</Volume>
            <Steps>0</Steps>
            <Unit>ML</Unit>
            <Calculation/>
          </Fluid>
          <Comments/>
        </Line>
        <Line Number="5">
          <Details>
            <Type>SUBSTANCE</Type>
            <Route>IVINF</Route>
            <InfusionHours>2</InfusionHours>
            <InfusionMinutes>0</InfusionMinutes>
            <ProductionBy>PHARMACY</ProductionBy>
            <RelationType>START</RelationType>
            <RelatedToDayNumber>3</RelatedToDayNumber>
            <RelatedToLineNumber>2</RelatedToLineNumber>
            <RelationOffset>720</RelationOffset>
          </Details>
          <Substance Name="cytarabin">
            <Dose Max="">1000</Dose>
            <Steps>0</Steps>
            <Unit>MG</Unit>
            <Calculation>SURFACE</Calculation>
          </Substance>
          <Fluid Name="Natriumklorid 9 mg/ml">
            <Volume>100</Volume>
            <Steps>0</Steps>
            <Unit>ML</Unit>
            <Calculation/>
          </Fluid>
          <Comments/>
        </Line>
      </Lines>
    </Day>
    <Day Number="4">
      <Details>
        <Name/>
        <ConfirmationMandatory>NO</ConfirmationMandatory>
        <Comment/>
      </Details>
      <CriticalParameters/>
      <Lines>
        <Line Number="1">
          <Details>
            <Type>FLUID</Type>
            <Route>IVINF</Route>
            <InfusionHours>24</InfusionHours>
            <InfusionMinutes>0</InfusionMinutes>
            <ProductionBy>WARD</ProductionBy>
            <RelationType>START</RelationType>
            <RelatedToDayNumber>3</RelatedToDayNumber>
            <RelatedToLineNumber>1</RelatedToLineNumber>
            <RelationOffset>1440</RelationOffset>
          </Details>
          <Fluid Name="Plasmalyte">
            <Volume>2000</Volume>
            <Steps>0</Steps>
            <Unit>ML</Unit>
            <Calculation>SURFACE</Calculation>
          </Fluid>
          <Comments>
            <Comment Text="Intravenös infusion - hydrering"/>
            <Comment Text="= totalvätska, man kan räkna av intag som tas per oralt. Vätska ges i samband med kemoterapi, kan avslutas 2 timmar efter avslutad Mitoxantron inf."/>
            <Comment Text="Kortison ögondroppar, 1 dr i vardera öga 3-4 ggr/dygn, förbygger cytarabin inducerad konjunktivit, även detta dygn som är dygnet efter given Cytarabin, kan förlängas några dagar vb."/>
          </Comments>
        </Line>
        <Line Number="2">
          <Details>
            <Type>ANTIDOTE</Type>
            <Route>IVINF</Route>
            <InfusionHours>0</InfusionHours>
            <InfusionMinutes>15</InfusionMinutes>
            <ProductionBy>WARD</ProductionBy>
            <RelationType>START</RelationType>
            <RelatedToDayNumber>3</RelatedToDayNumber>
            <RelatedToLineNumber>3</RelatedToLineNumber>
            <RelationOffset>1440</RelationOffset>
          </Details>
          <Substance Name="dexrazoxan">
            <Dose Max="">500</Dose>
            <Steps>0</Steps>
            <Unit>MG</Unit>
            <Calculation>SURFACE</Calculation>
          </Substance>
          <Fluid Name="Specialspädning">
            <Volume/>
            <Unit/>
            <Calculation/>
          </Fluid>
          <Comments>
            <Comment Text="VIKTIGT att Mitoxantron startas direkt efter avslutad Dexrazoxan"/>
          </Comments>
        </Line>
        <Line Number="3">
          <Details>
            <Type>SUBSTANCE</Type>
            <Route>IVINF</Route>
            <InfusionHours>1</InfusionHours>
            <InfusionMinutes>0</InfusionMinutes>
            <ProductionBy>PHARMACY</ProductionBy>
            <RelationType>END</RelationType>
            <RelatedToDayNumber>4</RelatedToDayNumber>
            <RelatedToLineNumber>2</RelatedToLineNumber>
            <RelationOffset>0</RelationOffset>
          </Details>
          <Substance Name="mitoxantron">
            <Dose Max="">10</Dose>
            <Steps>0</Steps>
            <Unit>MG</Unit>
            <Calculation>SURFACE</Calculation>
          </Substance>
          <Fluid Name="Natriumklorid 9 mg/ml">
            <Volume>100</Volume>
            <Steps>0</Steps>
            <Unit>ML</Unit>
            <Calculation/>
          </Fluid>
          <Comments/>
        </Line>
      </Lines>
    </Day>
    <Day Number="5">
      <Details>
        <Name/>
        <ConfirmationMandatory>NO</ConfirmationMandatory>
        <Comment/>
      </Details>
      <CriticalParameters/>
      <Lines>
        <Line Number="1">
          <Details>
            <Type>FLUID</Type>
            <Route>IVINF</Route>
            <InfusionHours>24</InfusionHours>
            <InfusionMinutes>0</InfusionMinutes>
            <ProductionBy>WARD</ProductionBy>
            <RelationType>START</RelationType>
            <RelatedToDayNumber>4</RelatedToDayNumber>
            <RelatedToLineNumber>1</RelatedToLineNumber>
            <RelationOffset>1440</RelationOffset>
          </Details>
          <Fluid Name="Plasmalyte">
            <Volume>2000</Volume>
            <Steps>0</Steps>
            <Unit>ML</Unit>
            <Calculation>SURFACE</Calculation>
          </Fluid>
          <Comments>
            <Comment Text="Intravenös infusion - hydrering"/>
            <Comment Text="= totalvätska, man kan räkna av intag som tas per oralt. Vätska ges i samband med kemoterapi, kan avslutas 2 timmar efter avslutad Mitoxantron inf."/>
            <Comment Text="Kortison ögondroppar, 1 dr i vardera öga 3-4 ggr/dygn, förbygger cytarabin inducerad konjunktivit, även detta dygn som är 2:a dygnet efter given Cytarabin, kan förlängas några dagar vb."/>
          </Comments>
        </Line>
        <Line Number="2">
          <Details>
            <Type>ANTIDOTE</Type>
            <Route>IVINF</Route>
            <InfusionHours>0</InfusionHours>
            <InfusionMinutes>15</InfusionMinutes>
            <ProductionBy>WARD</ProductionBy>
            <RelationType>START</RelationType>
            <RelatedToDayNumber>4</RelatedToDayNumber>
            <RelatedToLineNumber>2</RelatedToLineNumber>
            <RelationOffset>1440</RelationOffset>
          </Details>
          <Substance Name="dexrazoxan">
            <Dose Max="">500</Dose>
            <Steps>0</Steps>
            <Unit>MG</Unit>
            <Calculation>SURFACE</Calculation>
          </Substance>
          <Fluid Name="Specialspädning">
            <Volume/>
            <Unit/>
            <Calculation/>
          </Fluid>
          <Comments>
            <Comment Text="VIKTIGT att Mitoxantron startas direkt efter avslutad Dexrazoxan"/>
          </Comments>
        </Line>
        <Line Number="3">
          <Details>
            <Type>SUBSTANCE</Type>
            <Route>IVINF</Route>
            <InfusionHours>1</InfusionHours>
            <InfusionMinutes>0</InfusionMinutes>
            <ProductionBy>PHARMACY</ProductionBy>
            <RelationType>END</RelationType>
            <RelatedToDayNumber>5</RelatedToDayNumber>
            <RelatedToLineNumber>2</RelatedToLineNumber>
            <RelationOffset>0</RelationOffset>
          </Details>
          <Substance Name="mitoxantron">
            <Dose Max="">10</Dose>
            <Steps>0</Steps>
            <Unit>MG</Unit>
            <Calculation>SURFACE</Calculation>
          </Substance>
          <Fluid Name="Natriumklorid 9 mg/ml">
            <Volume>100</Volume>
            <Steps>0</Steps>
            <Unit>ML</Unit>
            <Calculation/>
          </Fluid>
          <Comments/>
        </Line>
      </Lines>
    </Day>
  </Days>
</CourseDefinition>
