<?xml version="1.0" encoding="ISO-8859-1" standalone="yes"?>
<CourseDefinition>
  <Schema>
    <Version>3.0</Version>
    <Date>20120717</Date>
  </Schema>
  <Details>
    <RegimId>NRB-13738</RegimId>
    <Name>Tislelizumab-FOLFOX</Name>
    <ShortName/>
    <MajorVersion>1</MajorVersion>
    <MinorVersion>3</MinorVersion>
    <DefinitionStatus>COMPLETED</DefinitionStatus>
    <PatientMaxSurface/>
    <CourseICDZCode>NONE</CourseICDZCode>
    <CourseAUC>0.00</CourseAUC>
    <MaxAge/>
    <CycleLength>42</CycleLength>
    <ValidForAllDiagnoses/>
    <IsStudyDefinition>NO</IsStudyDefinition>
    <PhysicianComment>Emetogenicitet:Medel.\n\nKurintervall: 42 dagar.\n\n</PhysicianComment>
    <NurseComment/>
    <PharmacistComment/>
    <PatientComment/>
    <ExternalDocumentation/>
    <ExternalPhysicianDoc>https://kunskapsbanken.cancercentrum.se/redirect/regim/13738</ExternalPhysicianDoc>
    <ExternalNurseDoc>https://kunskapsbanken.cancercentrum.se/redirect/regim/13738</ExternalNurseDoc>
    <ExternalPharmacistDoc/>
    <ExternalPatientDoc/>
    <Rounding/>
    <HasSteps/>
  </Details>
  <Miscellaneous>
    <OriginOfExport>Regimbiblioteket</OriginOfExport>
    <IsAuthorized/>
    <CommittedBy/>
    <CreatedBy/>
    <CreatedDate>20260327</CreatedDate>
  </Miscellaneous>
  <Diagnoses>
    <Diagnose Text="Matstrups- och magsäckscancer"/>
  </Diagnoses>
  <Protocols/>
  <AdditionalInformation/>
  <Days>
    <Day Number="1">
      <Details>
        <Name/>
        <ConfirmationMandatory>NO</ConfirmationMandatory>
        <Comment/>
      </Details>
      <CriticalParameters/>
      <Lines>
        <Line Number="1">
          <Details>
            <Type>FLUID</Type>
            <Route>IVINF</Route>
            <InfusionHours>0</InfusionHours>
            <InfusionMinutes>0</InfusionMinutes>
            <ProductionBy>WARD</ProductionBy>
            <RelationType>NONE</RelationType>
          </Details>
          <Fluid Name="Natriumklorid 9 mg/ml">
            <Volume>250</Volume>
            <Steps>0</Steps>
            <Unit>ML</Unit>
            <Calculation/>
          </Fluid>
          <Comments>
            <Comment Text="Spoldropp att fördelas mellan och efter sista läkemedlet"/>
          </Comments>
        </Line>
        <Line Number="2">
          <Details>
            <Type>ANTIDOTE</Type>
            <Route>PO</Route>
            <InfusionHours>0</InfusionHours>
            <InfusionMinutes>0</InfusionMinutes>
            <ProductionBy>WARD</ProductionBy>
            <RelationType>NONE</RelationType>
          </Details>
          <Substance Name="Antiemetika">
            <Dose Max="">0</Dose>
            <Unit>MG</Unit>
            <Calculation>STANDARD</Calculation>
          </Substance>
          <Fluid Name="Ej aktuellt">
            <Volume/>
            <Unit/>
            <Calculation/>
          </Fluid>
          <Comments>
            <Comment Text="Tablett/Injektion Antiemetika"/>
          </Comments>
        </Line>
        <Line Number="3">
          <Details>
            <Type>SUBSTANCE</Type>
            <Route>IVINF</Route>
            <InfusionHours>0</InfusionHours>
            <InfusionMinutes>30</InfusionMinutes>
            <ProductionBy>PHARMACY</ProductionBy>
            <RelationType>NONE</RelationType>
          </Details>
          <Substance Name="tislelizumab">
            <Dose Max="">400</Dose>
            <Steps>0</Steps>
            <Unit>MG</Unit>
            <Calculation>STANDARD</Calculation>
          </Substance>
          <Fluid Name="Natriumklorid 9 mg/ml">
            <Volume>100</Volume>
            <Steps>0</Steps>
            <Unit>ML</Unit>
            <Calculation/>
          </Fluid>
          <Comments>
            <Comment Text="Infusionstid 120 minuter ska användas om tislelizumab ges i dosen 400mg vid allra första kuren."/>
            <Comment Text="Om läkemedlet givits tidigare i dosen 200mg - ge den första högre dosen  (400mg) under 90 minuter. Om det gått bra kan nästa dos 400mg ges på 60 minuter. Om även den tolereras väl kan efterföljande behandlingar ges med infusionstid 30 min."/>
          </Comments>
        </Line>
        <Line Number="4">
          <Details>
            <Type>SUBSTANCE</Type>
            <Route>IVINF</Route>
            <InfusionHours>0</InfusionHours>
            <InfusionMinutes>60</InfusionMinutes>
            <ProductionBy>PHARMACY</ProductionBy>
            <RelationType>NONE</RelationType>
          </Details>
          <Substance Name="oxaliplatin">
            <Dose Max="">85</Dose>
            <Steps>0</Steps>
            <Unit>MG</Unit>
            <Calculation>SURFACE</Calculation>
          </Substance>
          <Fluid Name="Glukos 50 mg/ml">
            <Volume>250</Volume>
            <Steps>0</Steps>
            <Unit>ML</Unit>
            <Calculation/>
          </Fluid>
          <Comments/>
        </Line>
        <Line Number="5">
          <Details>
            <Type>ANTIDOTE</Type>
            <Route>IVINF</Route>
            <InfusionHours>0</InfusionHours>
            <InfusionMinutes>60</InfusionMinutes>
            <ProductionBy>WARD</ProductionBy>
            <RelationType>NONE</RelationType>
          </Details>
          <Substance Name="kalciumfolinat (vattenfritt)">
            <Dose Max="">400</Dose>
            <Steps>0</Steps>
            <Unit>MG</Unit>
            <Calculation>SURFACE</Calculation>
          </Substance>
          <Fluid Name="Glukos 50 mg/ml">
            <Volume>250</Volume>
            <Steps>0</Steps>
            <Unit>ML</Unit>
            <Calculation/>
          </Fluid>
          <Comments>
            <Comment Text="Ges parallellt med Oxaliplatin"/>
          </Comments>
        </Line>
        <Line Number="6">
          <Details>
            <Type>SUBSTANCE</Type>
            <Route>IVINJ</Route>
            <InfusionHours>0</InfusionHours>
            <InfusionMinutes>3</InfusionMinutes>
            <ProductionBy>PHARMACY</ProductionBy>
            <RelationType>NONE</RelationType>
          </Details>
          <Substance Name="fluorouracil">
            <Dose Max="">400</Dose>
            <Steps>0</Steps>
            <Unit>MG</Unit>
            <Calculation>SURFACE</Calculation>
          </Substance>
          <Fluid Name="Ingen spädning">
            <Volume/>
            <Unit/>
            <Calculation/>
          </Fluid>
          <Comments/>
        </Line>
        <Line Number="7">
          <Details>
            <Type>SUBSTANCE</Type>
            <Route>IVINF</Route>
            <InfusionHours>46</InfusionHours>
            <InfusionMinutes>0</InfusionMinutes>
            <ProductionBy>PHARMACY</ProductionBy>
            <RelationType>NONE</RelationType>
          </Details>
          <Substance Name="fluorouracil Bärbar infusionspump">
            <Dose Max="">2400</Dose>
            <Steps>0</Steps>
            <Unit>MG</Unit>
            <Calculation>SURFACE</Calculation>
          </Substance>
          <Fluid Name="Ingen spädning">
            <Volume/>
            <Unit/>
            <Calculation/>
          </Fluid>
          <Comments>
            <Comment Text="Efter 46 timmar kopplas pumpen bort."/>
          </Comments>
        </Line>
      </Lines>
    </Day>
    <Day Number="15">
      <Details>
        <Name/>
        <ConfirmationMandatory>NO</ConfirmationMandatory>
        <Comment/>
      </Details>
      <CriticalParameters/>
      <Lines>
        <Line Number="1">
          <Details>
            <Type>FLUID</Type>
            <Route>IVINF</Route>
            <InfusionHours>0</InfusionHours>
            <InfusionMinutes>0</InfusionMinutes>
            <ProductionBy>WARD</ProductionBy>
            <RelationType>NONE</RelationType>
          </Details>
          <Fluid Name="Natriumklorid 9 mg/ml">
            <Volume>250</Volume>
            <Steps>0</Steps>
            <Unit>ML</Unit>
            <Calculation/>
          </Fluid>
          <Comments>
            <Comment Text="Spoldropp att fördelas mellan och efter sista läkemedlet"/>
          </Comments>
        </Line>
        <Line Number="2">
          <Details>
            <Type>ANTIDOTE</Type>
            <Route>PO</Route>
            <InfusionHours>0</InfusionHours>
            <InfusionMinutes>0</InfusionMinutes>
            <ProductionBy>WARD</ProductionBy>
            <RelationType>NONE</RelationType>
          </Details>
          <Substance Name="Antiemetika">
            <Dose Max="">0</Dose>
            <Unit>MG</Unit>
            <Calculation>STANDARD</Calculation>
          </Substance>
          <Fluid Name="Ej aktuellt">
            <Volume/>
            <Unit/>
            <Calculation/>
          </Fluid>
          <Comments>
            <Comment Text="Tablett/Injektion Antiemetika"/>
          </Comments>
        </Line>
        <Line Number="3">
          <Details>
            <Type>SUBSTANCE</Type>
            <Route>IVINF</Route>
            <InfusionHours>0</InfusionHours>
            <InfusionMinutes>60</InfusionMinutes>
            <ProductionBy>PHARMACY</ProductionBy>
            <RelationType>NONE</RelationType>
          </Details>
          <Substance Name="oxaliplatin">
            <Dose Max="">85</Dose>
            <Steps>0</Steps>
            <Unit>MG</Unit>
            <Calculation>SURFACE</Calculation>
          </Substance>
          <Fluid Name="Glukos 50 mg/ml">
            <Volume>250</Volume>
            <Steps>0</Steps>
            <Unit>ML</Unit>
            <Calculation/>
          </Fluid>
          <Comments/>
        </Line>
        <Line Number="4">
          <Details>
            <Type>ANTIDOTE</Type>
            <Route>IVINF</Route>
            <InfusionHours>0</InfusionHours>
            <InfusionMinutes>60</InfusionMinutes>
            <ProductionBy>WARD</ProductionBy>
            <RelationType>NONE</RelationType>
          </Details>
          <Substance Name="kalciumfolinat (vattenfritt)">
            <Dose Max="">400</Dose>
            <Steps>0</Steps>
            <Unit>MG</Unit>
            <Calculation>SURFACE</Calculation>
          </Substance>
          <Fluid Name="Glukos 50 mg/ml">
            <Volume>250</Volume>
            <Steps>0</Steps>
            <Unit>ML</Unit>
            <Calculation/>
          </Fluid>
          <Comments>
            <Comment Text="Ges parallellt med Oxaliplatin"/>
          </Comments>
        </Line>
        <Line Number="5">
          <Details>
            <Type>SUBSTANCE</Type>
            <Route>IVINJ</Route>
            <InfusionHours>0</InfusionHours>
            <InfusionMinutes>3</InfusionMinutes>
            <ProductionBy>PHARMACY</ProductionBy>
            <RelationType>NONE</RelationType>
          </Details>
          <Substance Name="fluorouracil">
            <Dose Max="">400</Dose>
            <Steps>0</Steps>
            <Unit>MG</Unit>
            <Calculation>SURFACE</Calculation>
          </Substance>
          <Fluid Name="Ingen spädning">
            <Volume/>
            <Unit/>
            <Calculation/>
          </Fluid>
          <Comments/>
        </Line>
        <Line Number="6">
          <Details>
            <Type>SUBSTANCE</Type>
            <Route>IVINF</Route>
            <InfusionHours>46</InfusionHours>
            <InfusionMinutes>0</InfusionMinutes>
            <ProductionBy>PHARMACY</ProductionBy>
            <RelationType>NONE</RelationType>
          </Details>
          <Substance Name="fluorouracil Bärbar infusionspump">
            <Dose Max="">2400</Dose>
            <Steps>0</Steps>
            <Unit>MG</Unit>
            <Calculation>SURFACE</Calculation>
          </Substance>
          <Fluid Name="Ingen spädning">
            <Volume/>
            <Unit/>
            <Calculation/>
          </Fluid>
          <Comments>
            <Comment Text="Efter 46 timmar kopplas pumpen bort."/>
          </Comments>
        </Line>
      </Lines>
    </Day>
    <Day Number="29">
      <Details>
        <Name/>
        <ConfirmationMandatory>NO</ConfirmationMandatory>
        <Comment/>
      </Details>
      <CriticalParameters/>
      <Lines>
        <Line Number="1">
          <Details>
            <Type>FLUID</Type>
            <Route>IVINF</Route>
            <InfusionHours>0</InfusionHours>
            <InfusionMinutes>0</InfusionMinutes>
            <ProductionBy>WARD</ProductionBy>
            <RelationType>NONE</RelationType>
          </Details>
          <Fluid Name="Natriumklorid 9 mg/ml">
            <Volume>250</Volume>
            <Steps>0</Steps>
            <Unit>ML</Unit>
            <Calculation/>
          </Fluid>
          <Comments>
            <Comment Text="Spoldropp att fördelas mellan och efter sista läkemedlet"/>
          </Comments>
        </Line>
        <Line Number="2">
          <Details>
            <Type>ANTIDOTE</Type>
            <Route>PO</Route>
            <InfusionHours>0</InfusionHours>
            <InfusionMinutes>0</InfusionMinutes>
            <ProductionBy>WARD</ProductionBy>
            <RelationType>NONE</RelationType>
          </Details>
          <Substance Name="Antiemetika">
            <Dose Max="">0</Dose>
            <Unit>MG</Unit>
            <Calculation>STANDARD</Calculation>
          </Substance>
          <Fluid Name="Ej aktuellt">
            <Volume/>
            <Unit/>
            <Calculation/>
          </Fluid>
          <Comments>
            <Comment Text="Tablett/Injektion Antiemetika"/>
          </Comments>
        </Line>
        <Line Number="3">
          <Details>
            <Type>SUBSTANCE</Type>
            <Route>IVINF</Route>
            <InfusionHours>0</InfusionHours>
            <InfusionMinutes>60</InfusionMinutes>
            <ProductionBy>PHARMACY</ProductionBy>
            <RelationType>NONE</RelationType>
          </Details>
          <Substance Name="oxaliplatin">
            <Dose Max="">85</Dose>
            <Steps>0</Steps>
            <Unit>MG</Unit>
            <Calculation>SURFACE</Calculation>
          </Substance>
          <Fluid Name="Glukos 50 mg/ml">
            <Volume>250</Volume>
            <Steps>0</Steps>
            <Unit>ML</Unit>
            <Calculation/>
          </Fluid>
          <Comments/>
        </Line>
        <Line Number="4">
          <Details>
            <Type>ANTIDOTE</Type>
            <Route>IVINF</Route>
            <InfusionHours>0</InfusionHours>
            <InfusionMinutes>60</InfusionMinutes>
            <ProductionBy>WARD</ProductionBy>
            <RelationType>NONE</RelationType>
          </Details>
          <Substance Name="kalciumfolinat (vattenfritt)">
            <Dose Max="">400</Dose>
            <Steps>0</Steps>
            <Unit>MG</Unit>
            <Calculation>SURFACE</Calculation>
          </Substance>
          <Fluid Name="Glukos 50 mg/ml">
            <Volume>250</Volume>
            <Steps>0</Steps>
            <Unit>ML</Unit>
            <Calculation/>
          </Fluid>
          <Comments>
            <Comment Text="Ges parallellt med Oxaliplatin"/>
          </Comments>
        </Line>
        <Line Number="5">
          <Details>
            <Type>SUBSTANCE</Type>
            <Route>IVINJ</Route>
            <InfusionHours>0</InfusionHours>
            <InfusionMinutes>3</InfusionMinutes>
            <ProductionBy>PHARMACY</ProductionBy>
            <RelationType>NONE</RelationType>
          </Details>
          <Substance Name="fluorouracil">
            <Dose Max="">400</Dose>
            <Steps>0</Steps>
            <Unit>MG</Unit>
            <Calculation>SURFACE</Calculation>
          </Substance>
          <Fluid Name="Ingen spädning">
            <Volume/>
            <Unit/>
            <Calculation/>
          </Fluid>
          <Comments/>
        </Line>
        <Line Number="6">
          <Details>
            <Type>SUBSTANCE</Type>
            <Route>IVINF</Route>
            <InfusionHours>46</InfusionHours>
            <InfusionMinutes>0</InfusionMinutes>
            <ProductionBy>PHARMACY</ProductionBy>
            <RelationType>NONE</RelationType>
          </Details>
          <Substance Name="fluorouracil Bärbar infusionspump">
            <Dose Max="">2400</Dose>
            <Steps>0</Steps>
            <Unit>MG</Unit>
            <Calculation>SURFACE</Calculation>
          </Substance>
          <Fluid Name="Ingen spädning">
            <Volume/>
            <Unit/>
            <Calculation/>
          </Fluid>
          <Comments>
            <Comment Text="Efter 46 timmar kopplas pumpen bort."/>
          </Comments>
        </Line>
      </Lines>
    </Day>
  </Days>
</CourseDefinition>
