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Bilaga 5 - Klassifikation av MDS/MPN

Tabell 1. Klassifikation enligt WHO 2016 [47, 48]

Myelodysplastiska/myeloproliferativa neoplasier (MDS/MPN)

Kronisk myelomonocytleukemi (KMML)

Atypisk KML (aKML; BCR-ABL1-neg)

Juvenil myelomonocytleukemi (JMML)

MDS/MPN med ringsideroblaster och trombocytos (MDS/MPN-RS-T)

MDS/MPN, oklassificerbar (MDS/MPN-U)


Tabell 2. Klassifikation enligt WHO 2022, 5th edition (Khoury, 2022) 2

Myelodysplastiska/myeloproliferativa neoplasier (MDS/MPN)

Chronic myelomonocytic leukemia

  • Myelodysplastic CMML WBC < 13 x 109/L
  • Myeloproliferative CMML WBC > 13 x 109/L

CMML-1: < 5 % blast + promonocytes in PB and < 10 % in BM

CMML-2: 5–19 % blast + promonocytes in PB and 10–19 % in BM

Myelodysplastic/myeloproliferative neoplasms with neutrophilia
(former atypical CML)

Myelodysplastic/myeloproliferative neoplasms with SF3B1 and thrombocytosis

Myelodysplastic/myeloproliferative neoplasms, not otherwise specified


Tabell 3. Klassifikation enligt ICC (Arber 2022)[3]

Myelodysplastiska/myeloproliferativa neoplasier (MDS/MPN)

Clonal cytopenia with monocytosis of undetermined significance (CCMUS)

Clonal monocytosis of undetermined significance (CMUS)

Chronic myelomonocytic leukemia

Atypical chronic myeloid leukemia 

Myelodysplastic/myeloproliferative neoplasm with thrombocytosis and SF3B1 mutation 

Myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis, not otherwise specified 

Myelodysplastic/myeloproliferative neoplasm, not otherwise specified