Bilaga 5 - Klassifikation av MDS/MPN
Tabell 1. WHO 5th edition (Khoury, Leukemia 2022)
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Myelodysplastiska/myeloproliferativa neoplasier (MDS/MPN) |
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Chronic myelomonocytic leukemia • Myelodysplastic CMML WBC < 13 x 109/L • Myeloproliferative CMML WBC > 13 x 109/L CMML-1: < 5 % blast + promonocytes in PB and < 10 % in BM CMML-2: 5–19 % blast + promonocytes in PB and 10–19 % in BM |
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Myelodysplastic/myeloproliferative neoplasms with neutrophilia (former atypical CML) |
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Myelodysplastic/myeloproliferative neoplasms with SF3B1 and thrombocytosis |
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Myelodysplastic/myeloproliferative neoplasms, not otherwise specified |
Tabell 2. Klassifikation av MDS/MPN (Arber 2022) (ICC)
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Myelodysplastiska/myeloproliferativa neoplasier (MDS/MPN) |
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Clonal cytopenia with monocytosis of undetermined significance (CCMUS) |
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Clonal monocytosis of undetermined significance (CMUS) |
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Chronic myelomonocytic leukemia |
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Atypical chronic myeloid leukemia |
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Myelodysplastic/myeloproliferative neoplasm with thrombocytosis and SF3B1 mutation |
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Myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis, not otherwise specified |
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Myelodysplastic/myeloproliferative neoplasm, not otherwise specified |